{"id":2866,"date":"2024-05-06T16:05:00","date_gmt":"2024-05-06T16:05:00","guid":{"rendered":"https:\/\/sohl-lab.sdsu.edu\/?p=2866"},"modified":"2024-06-18T16:09:02","modified_gmt":"2024-06-18T16:09:02","slug":"check-out-our-latest-paper-in-nature-comm","status":"publish","type":"post","link":"http:\/\/sohl-lab.sdsu.edu\/index.php\/2024\/05\/06\/check-out-our-latest-paper-in-nature-comm\/","title":{"rendered":"Check out our latest paper in Nature Comm!"},"content":{"rendered":"\n<p>Check out our latest work in <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-48277-2\" data-type=\"link\" data-id=\"https:\/\/www.nature.com\/articles\/s41467-024-48277-2\">Nature Communications<\/a>! Here we show that distinct structural features in tumor-driving IDH1 mutants drive their unique catalytic profiles and lead to differences in an allosteric pocket that may impact inhibitor resistance. A great collaboration with Huxford and Cooksy labs here at the <a href=\"https:\/\/www.chemistry.sdsu.edu\">SDSU Chemistry and Biochemistry Department<\/a>!<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"692\" src=\"http:\/\/sohl-lab.sdsu.edu\/wp-content\/uploads\/2024\/06\/Screenshot-2024-06-18-at-9.06.01\u202fAM.png\" alt=\"\" class=\"wp-image-2867\" srcset=\"http:\/\/sohl-lab.sdsu.edu\/wp-content\/uploads\/2024\/06\/Screenshot-2024-06-18-at-9.06.01\u202fAM.png 800w, http:\/\/sohl-lab.sdsu.edu\/wp-content\/uploads\/2024\/06\/Screenshot-2024-06-18-at-9.06.01\u202fAM-300x260.png 300w, http:\/\/sohl-lab.sdsu.edu\/wp-content\/uploads\/2024\/06\/Screenshot-2024-06-18-at-9.06.01\u202fAM-768x664.png 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Check out our latest work in Nature Communications! Here we show that distinct structural features in tumor-driving IDH1 mutants drive their unique catalytic profiles and lead to differences in an allosteric pocket that may impact inhibitor resistance. A great collaboration &hellip; <a href=\"http:\/\/sohl-lab.sdsu.edu\/index.php\/2024\/05\/06\/check-out-our-latest-paper-in-nature-comm\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"ngg_post_thumbnail":0,"footnotes":""},"categories":[27,2],"tags":[3,4,22,8],"class_list":["post-2866","post","type-post","status-publish","format-standard","hentry","category-congrats","category-student-success","tag-big-news","tag-congrats","tag-papers","tag-student-success"],"_links":{"self":[{"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/posts\/2866","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/comments?post=2866"}],"version-history":[{"count":1,"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/posts\/2866\/revisions"}],"predecessor-version":[{"id":2868,"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/posts\/2866\/revisions\/2868"}],"wp:attachment":[{"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/media?parent=2866"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/categories?post=2866"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/tags?post=2866"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}