{"id":781,"date":"2017-08-09T14:35:32","date_gmt":"2017-08-09T14:35:32","guid":{"rendered":"http:\/\/sohl-lab.sdsu.edu\/?page_id=781"},"modified":"2024-06-17T18:59:23","modified_gmt":"2024-06-17T18:59:23","slug":"publications","status":"publish","type":"page","link":"https:\/\/sohl-lab.sdsu.edu\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

See our full publication list Publications<\/span><\/a>
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Key:<\/span> Undergraduate student author<\/span>;<\/span> Graduate student author; Postdoctoral trainee author<\/span><\/span><\/span><\/span><\/span><\/p>\n

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  1. Adam, M. A. A.<\/span>, Robinson M., Schwartz A. V., Wells G. A.,<\/span> Hoang A, Albekioni E., Chao G., Weeks J.,<\/span> George U. Z., House, C. D., Turcan S.*, Sohl C. D.*<\/u><\/strong> Catalytically distinct IDH1 mutants tune phenotype severity in tumor models. bioRxiv [Preprint]<\/em>. 2024 Apr 23; doi 10.1101\/2024.04.22.590655. (*corresponding authors<\/u><\/em>).<\/u><\/li>\n
  2. Thoman, D. B., Smith, J., L., Hernandez, I. A.<\/span>, Sohl, C. D.,<\/u><\/strong> and Villodas, M. T. (2024<\/strong>) Science<\/em> 384<\/em>, 747. \u201cUndergraduate research data crucial to equity. PMID38753783<\/a>.<\/li>\n
  3. Mealka, M.,<\/span> Sierra, N. A.,<\/span> Matteo, D. A., Albekioni, E.,<\/span> Khoury, R., Mai, T., <\/span>Conley, B. M.<\/span>, Coleman, N. J.,<\/span> Sabo, K. A.,<\/span> Komives, E. A., Bobkov, A. A., Cooksy, A. L., Silletti, S., Schiffer, J. M., Huxford, T., and Sohl, C. D.*<\/u><\/strong> (2024)<\/strong>Nature Comm 15, <\/em>3785.<\/em> \u201cActive site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms.\u201d (*corresponding author<\/u><\/em>).<\/u> PMID 38710674<\/a>.<\/li>\n
  4. Herrera, V., Charles, T., Scott, T., Prather, K., Nguyen, N., Sohl, C. D.<\/u><\/strong>, Thomas, L., and Richter-Addo, G. (2023)<\/strong>Biochemistry<\/em> 62, <\/em>1406-1419. \u201cInsights into nitrosoalkane binding to myoglobin provided by crystallography of wild-type and distal pocket mutant derivatives.\u201d PMID 37011611<\/a><\/li>\n
  5. Sabo, K. A., Albekioni, E.,<\/span> Caliger, D., Coleman, N. J., Thornberg, E.,<\/span> Matteo, D. A.,<\/span> Komives, E. A., Silletti, S., and Sohl, C. D.*<\/u> (2023)<\/strong> Biochemistry 62, <\/em>1146-1159. \u201cCapturing the dynamic conformational changes of human isocitrate dehydrogenase 1 (IDH1) upon ligand and metal binding using hydrogen-deuterium exchange mass spectrometry.\u201d (*corresponding author<\/u><\/em>).<\/u> PMID 36854124<\/a><\/li>\n
  6. Adam, M. A. A.<\/span>, and Sohl, C. D.*<\/u> (2022)<\/strong> Bioscience Reports, 42, <\/em> \u201cProbing altered enzyme activity in the biochemical characterization of cancer.\u201d (*corresponding author<\/u><\/em>).<\/u> PMID 35048115<\/li>\n
  7. Weeks, J.,<\/span> Strom, A.I., Widjaja, V., Alexander, S., Pucher, D.K.,<\/span> and Sohl, C. D.*<\/u><\/strong> (2021<\/strong>) Biomolecules, 11,<\/em> \u201cEvaluating mechanisms of IDH1 regulation through site-specific acetylation mimics.\u201d (*corresponding author<\/u><\/em>). <\/u>PMC8157008<\/a><\/li>\n
  8. Gross, S., and Sohl, C. D.*<\/u><\/strong> (2021<\/strong>) Biochem Mol Biol Edu, 49,<\/em> 407-415. \u201cReadying students for careers in industry: a guided inquiry activity to prepare students for success in biotechnology and pharmaceutical industry positions.\u201d (*corresponding author<\/u><\/em>) <\/u>PMID33569919<\/a><\/li>\n
  9. Luna, L. A.;<\/span> Lesecq, Z.;<\/span> White, K. A.; Hoang, A.; Scott, D. A.; Zagnitko, O.; Bobkov, A. A.; Barber, D. L.; Schiffer, J. M.; Isom, D. G.; and Sohl, C. D.* <\/u><\/strong>(2020<\/strong>) Biochemical J 477<\/em>, 2999-3018. \u201cAn acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.\u201d (*corresponding author<\/u><\/em>).<\/u> PMID32729927<\/a>.<\/em><\/li>\n
  10. Chambers, J.; Miller, W.; Quichocho, G.; Upadhye, V.;<\/span> Matteo, D. A.;<\/span> Bobkov, A.; Sohl, C. D.*<\/u>;<\/strong> and Schiffer, J. M.* (2020<\/strong>) Biochemistry 59, <\/em>479-490. \u201cWater networks and correlated motions in mutant IDH1 are critical for allosteric inhibitor binding and activity.\u201d (*corresponding authors<\/u><\/em>)<\/u> PMID31869219<\/a><\/li>\n
  11. Bernatchez, J. A.; Coste, M.;<\/span> Beck, S.; Wells, G. S.; Luna, L. A.; <\/span>Clark, A. E.; Zhu, Z.; Sohl, C. D.*<\/u>;<\/strong> Purse, B. W.*; Siqueira-Neto, J. L.* (2019<\/strong>) Viruses 11, <\/em>E365.<\/em> \u201cActivity of selected nucleoside analogue ProTides against Zika virus in human neural stem cells.\u201d (*corresponding authors<\/em>). <\/u>PMID31010044<\/a><\/li>\n
  12. Kennedy, M. A.<\/span>; Xu, Z.;<\/span> Wu, Y.;<\/span> and Sohl, C. D. (2019<\/strong>) Biochem Biophys Res Commun 509<\/em>, 898-902. A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhances cooperativity. PMID:30638931<\/a><\/li>\n
  13. Matteo, D. A.; Wells, G. A.; Luna, L. A.; Grunseth, A. J.;<\/span> Zagnitko, O.; Scott, D. A.; Hoang, A.; Luthra, A.;<\/span> Swairjo, M. A.; Schiffer, J. A.; and Sohl, C. D<\/u>. (2018<\/strong>) Biochem J 475, <\/em>3221-3238. <\/em>Inhibitor potency varies widely among tumor relevant human isocitrate dehydrogenase 1 mutants. PMID30257990<\/a><\/li>\n
  14. Bernatchez, J. A., Coste, M.,<\/span> Yang, Z., Li, J., Beck, S., Liu, Y., Clark, A. E., Zhu, Z., Luna, L. A.,<\/span> Sohl, C. D.,<\/u> Purse, B. W., Li, R., and Siqueira-Neto, J. L. (2018<\/strong>) Antimicrob Agents Chemother 62, <\/em>e00725-18. \u201cDevelopment of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus.\u201d PMID30257990<\/a>.<\/li>\n
  15. Matteo, D. M.*, Grunseth, A. J.*,<\/span> Gonzalez, E. R., Anselmo, S. L., Kennedy, M. A., Moman,<\/span> P.,<\/span> Scott, D. A., Hoang, A., and Sohl, C. D. <\/u>(2017<\/strong>) J Biol Chem 292, <\/em>7971-83. \u201cMolecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: the role of size and hydrophobicity at residue 132 on catalytic efficiency.\u201d (*co-first author<\/em>). <\/u><\/u>PMID:28330869<\/a>Publications prior to SDSU<\/strong><\/em><\/li>\n
  16. Ryan, M. R.; Sohl, C. D.<\/u>; Luo, B.; and Anderson, K. A. (2019<\/strong>) Mol Cancer Res 17,<\/em> 532-543. <\/em>The FGFR1 V561M gatekeeper mutation drives AZD4547 resistance through STAT3 activation and EMT. PMID30257990<\/a>.<\/li>\n
  17. Sohl, C. D., Ryan, M. R., Luo, B., Frey, K. M., and Anderson, K. S. (2015<\/strong>) ACS Chem Biol 10, <\/em>1319-29.<\/em> \u201cIlluminating the molecular mechanism of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles\u2019 heel of targeted therapy.\u201d<\/span><\/li>\n
  18. Sohl, C. D.<\/u>*, Szymanski, M. R.*, Mislak, A. C., Shumate, C. K., Amiralaei, S., Schinazi, R. F., Anderson, K. S., and Yin, Y. W. (2015<\/strong>) Proc Natl Acad Sci USA 112, <\/em>8596-601. <\/em>\u201cProbing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase g.\u201d (*co-first author<\/em>)<\/u>.<\/li>\n
  19. Sohl, C. D.*, Ray, S., and Sweasy, J. B. (2015<\/strong>) Proc Natl Acad Sci USA<\/em> 112<\/em>, 5864-5. \u201cPools and pols: mechanism of a mutator phenotype. (*co-first author<\/em>)<\/span><\/li>\n
  20. Towle-Weicksel, J. B., Dalal, S., Sohl, C. D., Doublie, S., Anderson, K. S., Sweasy, J. B. (2014<\/strong>) J Biol Chem 289, <\/em>16541-50. \u201cFluorescence resonance energy transfer studies of DNA polymerase \u00df: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.\u201d<\/span><\/li>\n
  21. Muftuoglu, Y.*, Sohl, C. D.*, <\/strong>Mislak, A. C., Mitsuya, H., Sarafianos, S. G., and Anderson, K. S. (2014<\/strong>) Antiviral Res<\/em> 106<\/em>, 1-4. \u201cProbing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4\u2019-ethynyl-2-fluoro-2\u2019-deoxyadenosine (EFdA) using pre-steady-state kinetics.\u201d (*co-first author<\/em>)<\/span><\/li>\n
  22. Sohl, C. D., Kasiviswanathan, R., Copeland, W. C., and Anderson, K. S. (2013<\/strong>) Hum Mol Genet 22<\/em>, 1074-85. \u201cMutations in human DNA polymerase g confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.\u201d <\/span><\/li>\n
  23. Cheng, Q., Sohl, C. D., Yoshimoto, F. K., and Guengerich, F. P. (2012<\/strong>) J Biol Chem<\/em> 287<\/em>, 59554-67. \u201cOxidation of dihydrotestosterone by human cytochromes P450s 19A1 and 3A4.\u201d <\/span><\/li>\n
  24. Sohl, C. D., Kasiviswanathan, R., Kim, J., Pradere, U., Schinazi, R. F., Copeland, W. C., Mitsuya, H., Baba, M., and Anderson, K. (2012<\/strong>) Mol Pharmacol 82, <\/em>125-33. \u201cBalancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.\u201d <\/span><\/li>\n
  25. Sohl, C. D., Singh, K., Kasiviswanathan, R., Copeland, W. C., Mitsuya, H., Sarafianos, S., and Anderson, K. (2012<\/strong>) Antimicrob Agents Chemother 56, <\/em>1630-4. \u201cMechanism of interaction of human mitochondrial DNA polymerase \u03b3 with the novel nucleoside reverse transcriptase inhibitor 4\u2019-ethynyl-2-fluoro-2\u2019-deoxyadenosine indicates a low potential for host toxicity.\u201d <\/span><\/li>\n
  26. Guengerich, F. P., Sohl, C. D., and Chowdhury, G. (2011<\/strong>) Arch Biochem Biophys 507, <\/em>126-34. \u201cMulti-step oxidations catalyzed by cytochrome P450 enzymes: processive distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms.\u201d
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  27. Sohl, C. D., and Guengerich, F. P. (2010<\/strong>) J Biol Chem 285<\/em>, 17734-17743. \u201cKinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.\u201d
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  28. Cheng, Q., Sohl, C. D., and Guengerich, F. P., (2009<\/strong>) Nat Protoc 4, <\/em>1258-61. \u201cHigh-throughput fluorescence assay of cytochrome P450 3A4.\u201d
    \n<\/span><\/li>\n
  29. Sohl, C. D., Cheng, Q., and Guengerich, F. P. (2009<\/strong>) Nat Protoc 4, <\/em>1252-7. \u201cChromatographic assays of drug oxidation by human cytochrome P450 3A4.\u201d
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  30. Guengerich, F. P., Martin, M. V., Sohl, C. D., and Cheng, Q. (2009<\/strong>) Nat Protoc<\/em> 4<\/em>, 1245-51. \u201cMeasurement of cytochrome P450 and NADPH-cytochrome P450 reductase.\u201d
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  31. Sohl, C. D., Isin, E. M., Eoff, R. L., Marsch, G. A., Stec, D. F., and Guengerich, F. P. (2008<\/strong>) J Biol Chem 283, <\/em>7293-7308. \u201cCooperativity in oxidation reactions catalyzed by cytochrome P450 1A2. Highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.\u201d
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  32. Isin, E. M.*, Sohl, C. D.*, Eoff, R. L., and Guengerich, F. P. (2008<\/strong>) Arch Biochem Biophys 473, <\/em>69-75. \u201cCooperativity of cytochrome P450 1A2: interaction of 1,4-phenylene diisocyanide and 1-alkoxy-4-nitrobenzenes.\u201d  (*co-first author<\/em>)<\/span><\/li>\n
  33. Wu, Z-L., Sohl, C. D., Shimada, T., and Guengerich, F. P. (2006<\/strong>) Mol Pharmacol<\/em> 69<\/em>, 2007-2014. \u201cRecombinant enzymes over-expressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1.\u201d
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  34. Sohl, C. D., Lee, J., Alguindigue, S. S., Khan, M. A., and Richter-Addo, G. B. (2004<\/strong>) J Inorg Biochem<\/em> 98<\/em>, 1238-46. \u201cSynthesis and solid-state molecular structures of nitrosoalkane complexes of iron porphyrins containing methanol, pyridine, and 1-methylimidazole ligands.\u201d
    \n<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    See our full publication list Key: Undergraduate student author; Graduate student author; Postdoctoral trainee author Adam, M. A. A., Robinson M., Schwartz A. V., Wells G. A., Hoang A, Albekioni E., Chao G., Weeks J., George U. Z., House, C. D., Turcan … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-781","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/pages\/781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/comments?post=781"}],"version-history":[{"count":12,"href":"https:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/pages\/781\/revisions"}],"predecessor-version":[{"id":2805,"href":"https:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/pages\/781\/revisions\/2805"}],"wp:attachment":[{"href":"https:\/\/sohl-lab.sdsu.edu\/index.php\/wp-json\/wp\/v2\/media?parent=781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}