Check out our latest work in Nature Communications! Here we show that distinct structural features in tumor-driving IDH1 mutants drive their unique catalytic profiles and lead to differences in an allosteric pocket that may impact inhibitor resistance. A great collaboration with Huxford and Cooksy labs here at the SDSU Chemistry and Biochemistry Department!
![](http://sohl-lab.sdsu.edu/wp-content/uploads/2024/06/Screenshot-2024-06-18-at-9.06.01 AM.png)